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This paper aims to focus on the changing role of universities in university–industry collaboration (UIC) for enriching the regional business ecosystem network. For this, the authors analyze “Business Clinic Day,” (BCD) a specific UIC program which provides a consulting service for firms, small- and medium-sized enterprises (SMEs) having a specific problem, by a group of facilitators. It includes consultants such as chief executive officers (CEOs), professors and heads of regional public or private service providers. This study illustrates that various types of networks are formed between consultants and problem-owners by facilitation of university after the program.

This study has analyzed with social network analysis how the business network was changed from clinic day program. Furthermore, the networks surrounding SMEs are extended to the other people connected to them. This means that the business network of SMEs had been diversified via the facilitation of “BCD” provided as UIC program.

Local SMEs have difficulties in enhancing their competitiveness in the market both in terms of internal resources and networks with external organizations. Thus, universities need to promote university–industry collaboration programs to enable SMEs to strengthen their competitiveness by building networks in local business ecosystems.

This study throws new highlights on the facilitator role of a university as a network promoter, in addition to the partner as a technology provider, in the regional business ecosystem.

The innovation process demands an interaction between environment agents, knowledge generators and policies of incentive for innovation and not only development by companies. Universities have gradually become the core of the knowledge production system and, therefore, their role regarding innovation has become more important and diversified. This study is aimed at identifying the mechanisms of university–industry (U–I) collaboration, as well as the operationalization steps of the U–I collaboration process.

This study is aimed at identifying, based on a systematic literature review, the mechanisms of university–industry (U–I) collaboration, as well as the operationalization steps of the U–I collaboration process.

The analysis of the 72 selected articles enabled identifying 15 mechanisms of U–I collaboration, proposing a new classification for such mechanisms and developing a framework presenting the operationalization steps of the interaction process.

In this paper, the authors screened nearly 1,500 papers and analyzed in detail 86 papers addressing U–I collaboration, mechanisms of U–I collaboration and operationalization steps of the U–I collaboration process. This paper provides a new classification for such mechanisms and developing a framework presenting the operationalization steps of the interaction process. This research contributes to both theory and practice by highlighting managerial aspects and stimulating academic research on such timely topic.